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Panthenol in Skincare

Panthenol in Skincare

Also known as provitamin B5, D-panthenol (dexpanthenol) is the most active isomeric form utilized for its moisturizing and soothing properties. Particularly effective in hydrating the skin and enhancing its texture and elasticity. Panthenol has become a promising skincare ingredient for those seeking to achieve softer, smoother, and healthier-looking skin.

What is Panthenol?

Panthenol is the stable biologically active form of pantothenic acid, also known as vitamin B5. It can be supplied as a racemic mixture of both dextrorotary form (dexpanthanol) and the levorotatory form (levopanthenol) meaning that the molecule comes in 2 forms that are mirror images of each other. Only the dexpanthenol is biologically active so it is important to look for skincare products calling out D-Panthenol or Dexpanthenol otherwise the panthenol in the product is likely a racemic mixture with half being the non-biologically active form levopanthenol. In skincare, panthenol is recognized for its ability to attract and hold moisture as well as soothe the skin. It's often used in a variety of skincare products, from creams and lotions to serums and masks.

What Does Panthenol Do to the Skin?

Panthenol performs on the skin by attracting water to the upper topical layer of the skin and holding it there, helping to improve skin hydration and thereby improving the appearance. It also has a soothing effect, which can help calm irritated skin. Additionally, when used on a consistent basis, panthenol can improve skin texture and elasticity. While both forms of panthenol can hydrate the skin, dexpanthenol works by enhancing epidermal differentiation and facilitating wound healing which overall aids in reinforcing the skin barrier.

Benefits of Panthenol:

The benefits of Panthenol in skin care include:


  • Hydration: Panthenol helps attract and hold moisture, keeping skin thoroughly hydrated.

  • Soothing: It can provide soothing relief to skin irritation.

  • Reinforce Skin Barrier: Panthenol can help improve the skin's barrier function, enhancing its resilience.

  • Plumping: With proper hydration levels, skin appears plump and healthy-looking.

How Does Panthenol Work?

By incorporating Panthenol into a skin care formula, the intent is to help improve hydration and support the skin barrier. Panthenol has been shown to attract atmospheric water to the upper layer of the skin and hold it there, helping to improve the overall look of skin. Its ability to improve skin texture and elasticity results in softer & smoother feeling skin. Dexpanthenol helps to calm irritated skin and has been shown to help reduce atopic dermatitis flare ups and frequency. Since it enhances wound healing it is also ideal for post-procedural treatments.

Concentration Levels & Recommended Usage for Panthenol

Panthenol is typically found in topical skincare products at concentrations of 0.5% to 5%. At these levels, the skin will benefit the most. It's often found in moisturizers, serums, and masks designed to hydrate and soothe the skin. For maximum results, it's recommended to use panthenol products consistently over a period of several weeks.

Is it Okay to Use Panthenol Daily?

Yes, Panthenol is generally gentle and safe for daily use. As always, a patch test is recommended when introducing a new skincare ingredient or product to ensure your skin agrees with it.

Who Should Use Panthenol?

Panthenol can be beneficial for anyone dealing with dry or irritated skin. It's particularly effective for those looking to improve skin hydration, soothe irritation, and achieve smoother, softer skin. It is also an amazing ingredient to incorporate after skin procedures and treatments. As always, it's best to consult with a skincare professional or dermatologist to determine if panthenol is right for your specific skin concerns.





DISCLAIMER: All skin care articles are intended to help educate on specific ingredients and skin care topics. Our articles are written to be informative and informational. Any reference to a specific patient experience is not a medical suggestion for treatment. Please note that any Prequel products with referenced ingredients are formulated for Cosmetic Use Only and NOT intended as replacements for physician advice and/or pharmaceutical product recommendations.





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