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cosmetic ingredients for skin barrier repair

Cosmetic Ingredients That Help Repair The Skin Barrier

The skin barrier is the outermost layer of the skin, responsible for keeping moisture in and harmful elements out. It is often described as having a brick and mortar structure with skin cells embedded in a lipid matrix that limits penetration of allergens, pollution, and microbes while helping skin retain its moisture content. When this barrier is compromised, skin can become dry, sensitive, and prone to irritation. It can also lead to skin concern flare ups such as eczema and rosacea.


Here's a list of ingredients known for their ability to help rejuvenate the skin barrier:

Ceramides: Barrier Reinforcement

Ceramides are lipids that naturally occur in the lipid barrier and are essential for maintaining the barrier function. Topically applied ceramides can help replenish the skin's natural ceramides and reinforce the skin's barrier, preventing moisture loss and protecting against environmental aggressors.

Hyaluronic Acid: Hydration Enhancement

Hyaluronic acid is a powerful polysaccharide and humectant naturally present in skin that draws moisture into the skin. It supports the skin barrier by providing hydration and can help to plump the skin, reducing the appearance of fine lines.

Cholesterol: Barrier Strengthening

Cholesterol, when used in skincare, works alongside fatty acids and ceramides, all components of the lipid matrix, to fortify the skin's barrier. It helps restore and maintain the health of the skin’s natural protective layer.

Fatty Acids: Lipid Layer Restoration

Fatty acids, including omega-3 and omega-6, are integral components of the skin barrier. They help to restore and maintain the lipid layer, improving skin's resilience.

Niacinamide: Barrier Function Improvement

Niacinamide, or Vitamin B3, helps strengthen the skin's barrier by increasing the production of ceramides and fatty acids in the skin. It improves the skin's ability to retain moisture and reduces potential for inflammation.

Squalane: Moisture Retention

Squalane is a stable hydrocarbon and emollient that mimics the skin's natural sebum. It is an excellent moisturizer that helps to replenish the skin barrier and restore suppleness.

Glycerin: Skin Barrier Protection

Glycerin is a humectant that attracts water to the skin and at levels between 20-45% can act as an OTC active skin protectant. It plays a crucial role in maintaining the barrier integrity and protecting the skin from irritants.

Panthenol: Skin Soothing

Panthenol, also known as Pro-Vitamin B5, helps soothe and replenish the skin barrier. It is known to have anti-inflammatory properties and has been clinically shown to improve skin's hydration, elasticity, and smooth appearance.


Incorporating these ingredients into your skincare routine can help restore and maintain a healthy skin barrier. It's important to choose products that contain a blend of these ingredients for comprehensive barrier care.





DISCLAIMER: All skin care articles are intended to help educate on specific ingredients and skin care topics. Our articles are written to be informative and informational. Any reference to a specific patient experience is not a medical suggestion for treatment. Please note that any Prequel products with referenced ingredients are formulated for Cosmetic Use Only and NOT intended as replacements for physician advice and/or pharmaceutical product recommendations.

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